Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
US8604183B2 · kind B2 · utility
12Cited by
402References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 4, 2003 |
| Grant date | Dec 10, 2013 |
| Priority date | — |
| Expiry date | Apr 20, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.