Pyridone and aza-pyridone compounds and methods of use

US8618107B2 · kind B2 · utility

Assignees

• GILEAD CONNECTICUT, INC. · US
• Genentech, Inc. · US

Inventors

• Antonio J.M. BARBOSA · Middlebury, US
• Peter A. Blomgren · Issaquah, US
• Kevin S. Currie · North Branford, US
• Ravi Krishnamoorthy · Guilderland, US
• Jeffrey E. Kropf · Branford, US
• Seung H. Lee · Sammamish, US
• Scott A. Mitchell · East Haven, US
• Daniel Fred Ortwine · San Ramon, US
• Aaron C. Schmitt · Hamden, US
• Xiaojing Wang · Foster City, US
• Jianjun Xu · Bellevue, US
• Wendy B. Young · San Mateo, US
• Honglu Zhang · Guilderland, US
• Zhongdong Zhao · Guilford, US
• Pavel E. Zhichkin · Latham, US

Key dates

• Filing date: May 6, 2011
• Grant date: Dec 31, 2013
• Expiry date: May 6, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.