Methods of using Bacillus anthracis protective antigen sequences for vaccination

US8703150B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Stephen H. Leppla · Bethesda, US
• Rachel Schneerson · Bethesda, US
• John B. Robbins · New York, US

Key dates

• Filing date: Sep 23, 2011
• Grant date: Apr 22, 2014
• Expiry date: Apr 13, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.