Methods of preparing substituted nucleotide analogs

US8846896B2 · kind B2 · utility

Assignees

• ALIOS BIOPHARMA, INC. · US
• Vertex Pharmaceuticals Incorporated · US

Inventors

• Vladimir Serebryany · Burlingame, US
• Jyanwei Liu · Sunnyvale, US
• Leonid Beigelman · San Mateo, US
• Young Chun Jung · Lexington, US
• Jamison Rose · Littleton, US
• Shereen Ibrahim · Cambridge, US
• Cavan McKeon · Tewksbury, US
• Luigi Anzalone · West Chester, US

Key dates

• Filing date: Mar 11, 2013
• Grant date: Sep 30, 2014
• Expiry date: Mar 11, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H1/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.