Substituted piperidines that increase p53 activity and the uses thereof

US8859776B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Stephane L. Bogen · Somerville, US
• Yao-Dong Ma · Richardson, US
• Yaolin Wang · Short Hills, US
• Brian Robert Lahue · Millbury, US
• Latha G. Nair · Edison, US
• Manami Shizuka · Lexington, US
• Matthew E. Voss · Singapore, SG
• Margarita Kirova-Snover · Troy, US
• Weidong Pan · Somerville, US
• Yuan Tian · Newton, US
• Bheemashankar A. Kulkarni · Noida, IN
• Craig R. Gibeau · Holliston, US
• Yuan Liu · Billerica, US
• Giovanna Scapin · Staten Island, US
• Diane Rindgen · North Plainfield, US
• Ronald J. Doll · Maplewood, US
• Timothy J. Guzi · Chatham, US
• Danny J. Hicklin · Montclair, US
• Amin Nomeir · Milford, US
• Gerald W. Shipps, Jr. · Stoneham, US
• Malcolm MacCoss · Freehold, US

Key dates

• Filing date: Oct 5, 2010
• Grant date: Oct 14, 2014
• Expiry date: Jul 8, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of Formula 1as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.