Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C

US8877775B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Ralf Anderskewitz · Laupheim, DE
• Matthias Grauert · Ingelheim am Rhein, DE
• Marc Grundl · Biberach an der Riß, DE
• Thorsten Oost · Biberach an der Riß, DE
• Alexander Pautsch · Ulm, DE
• Stefan Peters · Biberach an der Riß, DE

Key dates

• Filing date: Mar 12, 2014
• Grant date: Nov 4, 2014
• Expiry date: Mar 12, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.