Engineering of systems, methods and optimized guide compositions for sequence manipulation
US8906616B2 · kind B2 · utility
422Cited by
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30Claims
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Key dates
| Filing date | May 29, 2014 |
| Grant date | Dec 9, 2014 |
| Priority date | — |
| Expiry date | May 29, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B30/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.