Nucleic acid chemical modifications
US8975389B2 · kind B2 · utility
27Cited by
7References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 2, 2010 |
| Grant date | Mar 10, 2015 |
| Priority date | — |
| Expiry date | Jan 28, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/336
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.