Patent · US Active

Compositions and methods for modulation of SMN2 splicing in a subject

US8980853B2 · kind B2 · utility

30Cited by

18References

4Claims

0Family size

Assignees

Isis Pharmaceuticals, Inc. · US
Cold Spring Harbor Laboratory · US

Inventors

C. Frank Bennett · Carlsbad, US
Gene Hung · San Francisco, US
Frank Rigo · Carlsbad, US
Adrian R. Krainer · Huntington Station, US
Yimin Hua · Los Altos, US
Marco A. Passini · Northborough, US
Lamya Shihabuddin · Watertown, US
Seng H. Cheng · Wellesley, US
Katherine W. Klinger · Sudbury, US

Key dates

Filing date	Jun 17, 2010
Grant date	Mar 17, 2015
Priority date	—
Expiry date	Nov 24, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/33
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.