Patent · US Active

Nuclease resistant double-stranded ribonucleic acid

US8993746B2 · kind B2 · utility

3Cited by

1References

10Claims

0Family size

Assignee

Alnylam Pharmaceuticals, Inc. · US

Inventors

Hans-Peter Vornlocher · Bayreuth, DE
Ingo Roehl · Memmelsdorf, DE
Philipp Hadwiger · Kulmbach, DE
Tracy Zimmermann · Cambridge, US
Muthiah Manoharan · Carlsbad, US
Kallanthottathil G. Rajeev · Wayland, US
Akin Akinc · Cambridge, US

Key dates

Filing date	Mar 27, 2012
Grant date	Mar 31, 2015
Priority date	—
Expiry date	Mar 27, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/51
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.