Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
US9220728B2 · kind B2 · utility
36Cited by
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30Claims
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Key dates
| Filing date | Aug 27, 2012 |
| Grant date | Dec 29, 2015 |
| Priority date | — |
| Expiry date | Mar 15, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.