Compositions and methods for silencing genes expressed in cancer
US9222086B2 · kind B2 · utility
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Key dates
| Filing date | Sep 23, 2010 |
| Grant date | Dec 29, 2015 |
| Priority date | — |
| Expiry date | May 17, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides therapeutic nucleic acids such as interfering RNA (e.g., siRNA) that target the expression of genes associated with tumorigenesis and/or cell transformation, lipid particles (e.g., nucleic acid-lipid particles) comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles, e.g., for the treatment of a cell proliferative disorder such as cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.