Compositions and methods of treating head and neck cancer

US9370551B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US
• Massachusetts Eye and Ear Infirmary · US
• DANA-FARBER CANCER INSTITUTE, INC. · US
• University of Pittsburgh—Of the Commonwealth System of Higher Education · US
• INSTITUTO CARLOS SLIM DE LA SALUD, A.C. · MX

Inventors

• Le Cong · Cambridge, US
• Ann Marie Egloff · Pittsburgh, US
• Levi A. Garraway · Newton, US
• Jennifer Rubin Grandis · Pittsburgh, US
• Eric S. Lander · Cambridge, US
• Nicholas Stransky · Boston, US
• Aaron D. Tward · Boston, US
• Feng Zhang · Tianjin, CN

Key dates

• Filing date: Jul 25, 2012
• Grant date: Jun 21, 2016
• Expiry date: Jan 16, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2999/007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features methods which may specifically target HNSCC-associated genes and alter gene expression to treat or alleviate a symptom of HNSCC, or its related premalignant lesions. These methods may involve decreasing the function of an HNSCC-associated gene with aberrant gain-of-function; or increasing the function of an HNSCC-associated gene with aberrant loss-of-function.