Patent · US Active

Substituted pyrrolidines as SYK inhibitors

US9376441B2 · kind B2 · utility

13Cited by
6References
20Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 31, 2014
Grant dateJun 28, 2016
Priority date—
Expiry dateAug 23, 2034

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D519/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.