HIV-1 broadly neutralizing antibodies

US9382311B2 · kind B2 · utility

Assignees

• International AIDS Vaccine Initiative, Inc. · US
• THE SCRIPPS RESEARCH INSTITUTE · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• John Mascola · Rockville, US
• Dennis R. Burton · Village of La Jolla, US
• Wayne Koff · Stony Brook, US
• Peter Kwong · Washington, US
• Gary J. Nabel · Cambridge, US
• Sanjay K. Phogat · Frederick, US
• Pascal Raymond Georges Poignard · San Diego, US
• Melissa Danielle De Jean De St. Marcel Simek-Lemos · Brooklyn, US
• Xueling Wu · Potomac, US
• Tongqing Zhou · Boyds, US
• Zhi-yong Yang · Potomac, US

Key dates

• Filing date: Mar 10, 2013
• Grant date: Jul 5, 2016
• Expiry date: Mar 10, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates broadly neutralizing monoclonal antibodies directed against HIV-1. In particular, monoclonal antibodies VRC-PG04 and VRC-PG05 are disclosed.