Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use

US9403829B2 · kind B2 · utility

Assignee

• Signal Pharmaceuticals, LLC · US

Inventors

• Terrence Joseph Connolly · Rocky Hill, US
• Kevin J. Klopfer · Flemington, US
• William W. Leong · Westfield, US
• Anil Menon · Bound Brook, US
• Amanda Nicole Miklos · Hoboken, US
• Nathan Boersen · Summit, US
• Benjamin M. Cohen · Cranford, US
• Juan Antonio Gamboa · New York, US
• Ho-Wah Hui · Berkeley Heights, US
• Matthew Michael Kreilein · Fryeburg, US
• Thomas Lee · Bedminster, US
• Ying Li · Millburn, US
• Jean Xu · Hackettstown, US

Key dates

• Filing date: Nov 30, 2012
• Grant date: Aug 2, 2016
• Expiry date: Apr 23, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.