Substituted oxetanes and their use as inhibitors of cathepsin C

US9440960B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Matthias Grauert · Ingelheim am Rhein, DE
• Ralf Anderskewitz · Laupheim, DE
• Achim Bixenmann · Munderkingen, DE
• Marc Grundl · Biberach an der Riß, DE
• Peter Wilhelm HAEBEL · Mittelbiberach, DE
• Alexander Pautsch · Ulm, DE

Key dates

• Filing date: Jul 31, 2015
• Grant date: Sep 13, 2016
• Expiry date: Jul 31, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a compound of formula Iand their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.