Systems and methods for multiple analyte detection

US9714444B2 · kind B2 · utility

Assignee

• Applied Biosystems, LLC · US

Inventors

• Min Yue · Belmont, US
• David M. Liu · Los Altos, US
• Joy Roy · San Jose, US
• Yuh-Min Chiang · Sunnyvale, US
• Joon Mo Yang · San Diego, US
• Dennis Lehto · Santa Clara, US
• Charles S. Vann · El Granada, US
• Nigel P. Beard · San Diego, US
• Ian A. Harding · San Mateo, US
• John R. Van Camp · San Ramon, US
• Alexander Dromaretsky · Davis, US
• Sergey V. Ermakov · Castro Valley, US
• Mark F. Oldham · Los Gatos, US
• Maryam Shariati · Sunnyvale, US
• Umberto Ulmanella · Foster City, US

Key dates

• Filing date: Dec 2, 2013
• Grant date: Jul 25, 2017
• Expiry date: May 24, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/2575
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.