Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents

US9777013B2 · kind B2 · utility

Assignees

• William Marsh Rice University · US
• THE SCRIPPS RESEARCH INSTITUTE · US
• Bristol-Myers Squibb Company · US

Inventors

• Kyriacos C. Nicolaou · Philadelphia, US
• Min Lu · San Diego, US
• Debashis Mandal · Fremont, US
• Sanjeev Gangwar · Foster City, US
• Naidu S. Chowdari · Sunnyvale, US
• Yam B. Poudel · Fremont, US

Key dates

• Filing date: Aug 14, 2014
• Grant date: Oct 3, 2017
• Expiry date: Aug 14, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).