Amide substituted thiazoles as modulators of RORyt

US9845319B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Steven Goldberg · Encinitas, US
• Hariharan Venkatesan · San Diego, US
• Virginia M. Tanis · Carlsbad, US
• Maud Urbanski · Flemington, US
• Aihua Wang · Jamison, US
• David A. Kummer · San Diego, US
• Christoph Steeneck · Dossenheim, DE
• Christian Gege · Ehingen (Donau), DE
• Olaf Kinzel · Heidelberg, DE
• Gerald Kleymann · Bad Salzuflen, DE
• Thomas Hoffmann · Santa Cruz, US
• Anne Fourie · San Diego, US
• Xiaohua Xue · San Diego, US

Key dates

• Filing date: Oct 30, 2015
• Grant date: Dec 19, 2017
• Expiry date: Oct 30, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention comprises compounds of Formula I.wherein:R1, R2, R3, R5, A1, A2, andare defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.