Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
US9968601B2 · kind B2 · utility
7Cited by
26References
53Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 5, 2016 |
| Grant date | May 15, 2018 |
| Priority date | — |
| Expiry date | Apr 17, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.