Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses

USRE45016E1 · kind E1 · reissue

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Stephen S. Whitehead · Montgomery Village, US
• Brian R. Murphy · Bethesda, US
• Kathryn A. Hanley · Las Cruces, US
• Joseph E. Blaney · Frederick, US
• Ching-Juh Lai · Bethesda, US

Key dates

• Filing date: May 17, 2013
• Grant date: Jul 15, 2014
• Expiry date: May 17, 2033

Classification

• Technology area (CPC —): General

Abstract

A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.