Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3′-UTR of dengue types 1,2,3, and 4, or antigenic chimeric dengue viruses 1,2,3, and 4

USRE46631E1 · kind E1 · reissue

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Stephen S. Whitehead · Montgomery Village, US
• Brian R. Murphy · Bethesda, US
• Lewis Markoff · Bethesda, US
• Barry Falgout · Rockville, US
• Joseph E. Blaney · Frederick, US
• Kathryn A. Hanley · Las Cruces, US
• Ching-Juh Lai · Bethesda, US

Key dates

• Filing date: May 17, 2013
• Grant date: Dec 12, 2017
• Expiry date: May 17, 2033

Classification

• Technology area (CPC —): General

Abstract

The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3′-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.