Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom

US9156873B2 · kind B2 · utility

Assignees

• Isis Pharmaceuticals, Inc. · US
• Alnylam Pharmaceuticals, Inc. · US

Inventors

• Thazha P. Prakash · Carlsbad, US
• Punit P. Seth · Carlsbad, US
• Muthiah Manoharan · Carlsbad, US
• Eric E. Swayze · Carlsbad, US
• Kallanthottathil G. Rajeev · Wayland, US
• Ivan Zlatev · Cambridge, US

Key dates

• Filing date: Apr 26, 2011
• Grant date: Oct 13, 2015
• Expiry date: Feb 1, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/113
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein are modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom. More particularly, modified 5′ diphosphate nucleosides are provided that can be further modified at the 2′ and 5′ positions. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The oligomeric compounds are also expected to be useful as primers and probes in diagnostic applications.